Guziliayi Kuerban, Ablajan Turak, Jiangyu Zhao, Haji Akber Aisa
Phytochemistry 2024 MarInvestigation on the chemical constituents of Artemisia scoparia resulted in the isolation of sixteen compounds, including undescribed six pairs of diprenylated phenolic enantiomers (±)-scopacoumaricin A-F, and two pairs of cis-trans isomers cis/trans-scopacoumaricin G and cis/trans-artepillin A. Trans-artepillin A was obtained from this plant for the first time. The structures of the isolates were proposed by analysis of their 1D, 2D-NMR and HRESIMS spectroscopic data. Their absolute configurations were determined by comparison of their experimental and calculated electronic circular dichroism spectra. Evaluations of the anti-inflammatory activity revealed that (-)-scopacoumaricin D, (+)-scopacoumaricin F and cis-scopacoumaricin G showed moderate anti-inflammatory activity on lipopolysaccharide-induced nitric oxide production in RAW264.7 cell. Copyright © 2024 Elsevier Ltd. All rights reserved.
Guziliayi Kuerban, Ablajan Turak, Jiangyu Zhao, Haji Akber Aisa. Diprenylated phenolic enantiomers from Artemisia scoparia. Phytochemistry. 2024 Mar;219:113991
PMID: 38242272
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