Asymmetry of Dual-Display DNA-Encoded Chemical Libraries.

While dual-display DNA-encoded chemical libraries (DELs) are increasingly employed for ligand discovery, some of their fundamental properties have not yet been studied in-depth. Aided with fluorescence polarization experiments, we demonstrate that dual-display DELs are intrinsically asymmetrical entities, and we deduce practical guidelines to perform better-informed on-DNA hit validation from these libraries.

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Louise Plais, Louis Trachsel, Jörg Scheuermann. Asymmetry of Dual-Display DNA-Encoded Chemical Libraries. Bioconjugate chemistry. 2024 Feb 21;35(2):147-153

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PMID: 38266192

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