Human Xenograft Model.

Shuang Liu

Methods in molecular biology (Clifton, N.J.) 2024

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Human-SCID grafting is a commonly used technique for the long-term investigation of rheumatoid arthritis (RA) explants. To establish a chimeric immunological system in NOD/SCID mice, RA patient-derived pannus tissue from the synovial membrane, articular cartilage, and bone can be transplanted subcutaneously. Same patient-derived peripheral mononuclear cell chimerism can be successfully achieved by intraperitoneal engraftment. This xenograft model is able to be used for the initial screening of human target-specified biologics. © 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.