The Functional Assessment of T Cells.

Saho Maruyama

Methods in molecular biology (Clifton, N.J.) 2024

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It is important to know what kind of T-cell populations are involved in various disease states, and to know the state of T-cell functions involving in the disease. When a T cell's antigen receptors (TCR) recognize a specific antigen, the cell transmits a signal by a transduction mechanism within the T cell's cytoplasm. This signal initiates gene transcription essential for differentiation and activation of T cells. In this chapter, we will describe the methods of analyzing the transcribed mRNA and detecting the translated product in order to know the activation state of T cells. © 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.