Nephrotic proteinuria and hematuria with newly diagnosed IgA nephropathy after liver transplant: A case report.

Tingli Wang, Honghong Ren, Dan Yin, Hongyu Qiu

Transplant immunology 2024 Apr

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IgA nephropathy is a renal lesion in patients with end-stage liver disease, called hepatic IgA nephropathy. The common manifestation of hepatic IgA nephropathy is microscopic hematuria. Sirolimus, often used to prevent organ rejection, has been reported to induce proteinuria after organ transplantation. But few cases of nephrotic proteinuria and hematuria are reported. In this case, a 45-year-old male with a long history of hepatic B virus infection and liver cirrhosis, received liver transplant and was taking sirolimus as one of his immunosuppression drugs. Overt proteinuria and hematuria occurred. With no proteinuria history before, renal biopsy was performed, which indicated IgA nephropathy. We reported a liver recipient, who was taking sirolimus, developing nephrotic proteinuria and hematuria with IgA nephropathy. Further studies need to be carried out to disclose mechanism behind this phenomenon. Copyright © 2024. Published by Elsevier B.V.

Citation

Tingli Wang, Honghong Ren, Dan Yin, Hongyu Qiu. Nephrotic proteinuria and hematuria with newly diagnosed IgA nephropathy after liver transplant: A case report. Transplant immunology. 2024 Apr;83:102003