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    Herein, we report on an artificial nickel chlorinase (ANCase) resulting from anchoring a biotinylated nickel-based cofactor within streptavidin (Sav). The resulting ANCase was efficient for the chlorination of diverse C(sp3)-H bonds. Guided by the X-ray analysis of the ANCase, the activity of the artificial chlorinase could be significantly improved. This approach opens interesting perspectives for late-stage functionalization of organic intermediates as it complements biocatalytic chlorination strategies.

    Citation

    Kun Yu, Kailin Zhang, Roman P Jakob, Timm Maier, Thomas R Ward. An artificial nickel chlorinase based on the biotin-streptavidin technology. Chemical communications (Cambridge, England). 2024 Feb 13;60(14):1944-1947

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    PMID: 38277163

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