A single locus determines praziquantel response in Schistosoma mansoni.

We previously performed a genome-wide association study (GWAS) to identify the genetic basis of praziquantel (PZQ) response in schistosomes, identifying two quantitative trait loci situated on chromosomes 2 and 3. We reanalyzed this GWAS using the latest (version 10) genome assembly showing that a single locus on chromosome 3, rather than two independent loci, determines drug response. These results reveal that PZQ response is monogenic and demonstrates the importance of high-quality genomic information.

Citation

Frédéric D Chevalier, Winka Le Clec'h, Matthew Berriman, Timothy J C Anderson. A single locus determines praziquantel response in Schistosoma mansoni. Antimicrobial agents and chemotherapy. 2024 Mar 06;68(3):e0143223

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PMID: 38289079

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