Strachan's syndrome and riboflavin deficiency.

Caroline Kramarz, James McHugh, Alexander Rossor

Practical neurology 2024 Mar 19

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Strachan's syndrome comprises a triad of optic, auditory and painful sensory peripheral neuropathy. It has been recognised since the late 19th century and is presumed to result from nutritional deficiency. Patients present acute or subacutely after a period of systemic illness, weight loss or, most commonly, dietary restriction, especially veganism, which can cause riboflavin (vitamin B2) and vitamin B12 deficiencies. The syndrome is more common in people who are black British and often of Jamaican descent. We describe the clinical phenotype using a typical case example, review other endemic nutritional peripheral neuropathies and discuss the potential benefit of riboflavin as a treatment. © Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.