Synthesis and Structural Characterization of Macrocyclic α-ABpeptoids and Their DNA-Encoded Library.

The first synthesis of macrocyclic α-ABpeptoids with varying lengths is described. X-ray crystal structures reveal that cyclic trimer displays a chair-like conformation with a cct amide sequence and cyclic tetramer has a saddle-like structure with an uncommon cccc amide arrangement. The creation of a DNA-encoded combinatorial library of macrocyclic α-ABpeptoids is described.

Citation

Soobin Lee, Hyunchul Kwon, Eun-Kyoung Jee, Jaelim Kim, Kang Ju Lee, Jungyeon Kim, Nakeun Ko, Eunsung Lee, Hyun-Suk Lim. Synthesis and Structural Characterization of Macrocyclic α-ABpeptoids and Their DNA-Encoded Library. Organic letters. 2024 Feb 09;26(5):1100-1104

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PMID: 38295374

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