Ling Zhang, Jing Zhao, Sin Man Lam, Lang Chen, Yingzhuo Gao, Wenjie Wang, Yuyan Xu, Tianyu Tan, Hua Yu, Min Zhang, Xufeng Liao, Mengchen Wu, Tianyun Zhang, Jie Huang, Bowen Li, Quan D Zhou, Ning Shen, Hyeon Jeong Lee, Cunqi Ye, Da Li, Guanghou Shui, Jin Zhang
Nature cell biology 2024 FebLipids are indispensable for energy storage, membrane structure and cell signalling. However, dynamic changes in various categories of endogenous lipids in mammalian early embryonic development have not been systematically characterized. Here we comprehensively investigated the dynamic lipid landscape during mouse and human early embryo development. Lipid signatures of different developmental stages are distinct, particularly for the phospholipid classes. We highlight that the high degree of phospholipid unsaturation is a conserved feature as embryos develop to the blastocyst stage. Moreover, we show that lipid desaturases such as SCD1 are required for in vitro blastocyst development and blastocyst implantation. One of the mechanisms is through the regulation of unsaturated fatty-acid-mediated fluidity of the plasma membrane and apical proteins and the establishment of apical-basal polarity during development of the eight-cell embryo to the blastocyst. Overall, our study provides an invaluable resource about the remodelling of the endogenous lipidome in mammalian preimplantation embryo development and mechanistic insights into the regulation of embryogenesis and implantation by lipid unsaturation. © 2024. The Author(s), under exclusive licence to Springer Nature Limited.
Ling Zhang, Jing Zhao, Sin Man Lam, Lang Chen, Yingzhuo Gao, Wenjie Wang, Yuyan Xu, Tianyu Tan, Hua Yu, Min Zhang, Xufeng Liao, Mengchen Wu, Tianyun Zhang, Jie Huang, Bowen Li, Quan D Zhou, Ning Shen, Hyeon Jeong Lee, Cunqi Ye, Da Li, Guanghou Shui, Jin Zhang. Low-input lipidomics reveals lipid metabolism remodelling during early mammalian embryo development. Nature cell biology. 2024 Feb;26(2):278-293
PMID: 38302721
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