Challenges in distinguishing functional proteins from polyproteins in databases: implications for drug discovery.

This opinion article addresses a major issue in molecular biology and drug discovery by highlighting the complications that arise from combining polyproteins and their functional products within the same database entry. This problem, exemplified by the discovery of novel inhibitors for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease, has an influence on our ability to retrieve precise data and hinders the development of targeted therapies. It also emphasizes the need for improved database practices and underscores their significance in advancing scientific research. Furthermore, it emphasizes the need of learning from the SARS-CoV-2 pandemic in order to improve global preparedness for future health crises. © The Author(s) 2024. Published by Oxford University Press.

Citation

Ariadna Llop-Peiró, Gerard Pujadas, Santiago Garcia-Vallvé. Challenges in distinguishing functional proteins from polyproteins in databases: implications for drug discovery. Briefings in bioinformatics. 2024 Jan 22;25(2)

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PMID: 38305454

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