Diagnostic performance of pressure-bounded coronary flow reserve.

Fluid dynamics studies have proposed that coronary flow reserve can be calculated from coronary artery pressure instead of coronary blood flow. We sought to investigate the diagnostic performance of pressure-bounded coronary flow reserve (pb-CFR) compared with CFR measured by conventional thermodilution method (CFRthermo) in the clinical setting. Pressure guidewire was used to measure CFRthermo and fractional flow reserve (FFR) in left anterior descending coronary artery in 62 patients with stable coronary artery disease. Pb-CFR was calculated only with resting distal coronary artery pressure (Pd), resting aortic pressure (Pa) and FFR. Pb-CFR was moderately correlated with CFRthermo (r = 0.54, P < 0.001). Pb-CFR showed a poor agreement with CFRthermo, presenting large values of mean difference and root mean square deviation (1.5 ± 1.4). Pb-CFR < 2.0 predicted CFRthermo < 2.0 with an accuracy of 79%, sensitivity of 83%, specificity of 78%, positive predictive value of 48%, negative predictive value of 95%. The discordance presenting CFRthermo < 2.0 and pb-CFR ≥ 2.0 was associated with diffuse disease (P < 0.001). The discordance presenting CFRthermo ≥ 2 and pb-CFR < 2 was associated with a high FFR (P = 0.002). Pb-CFR showed moderate correlation and poor agreement with CFRthermo. Pb-CFR might be reliable in excluding epicardial coronary artery disease and microcirculatory disorders. © 2024. The Author(s) under exclusive licence to Japanese Association of Cardiovascular Intervention and Therapeutics.

Citation

Kazumasa Ikeda, Takashi Kubo, Takahide Murasawa, Haruyuki Deguchi, Kazuya Takihara, Masato Nukariya, Asuka Kuwahara, Tomoaki Nakayama, Miki Kitamura, Taiyo Tezuka, Ryu Takagi, Ryosuke Ito, Shuichiro Kazawa, Yoichi Iwasaki, Satoshi Yamada, Kazuhiro Satomi, Nobuhiro Tanaka. Diagnostic performance of pressure-bounded coronary flow reserve. Cardiovascular intervention and therapeutics. 2024 Apr;39(2):164-172

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PMID: 38329574

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