Self-control is associated with health-relevant disparities in buccal DNA-methylation measures of biological aging in older adults.

Y E Willems, A deSteiguer, P T Tanksley, L Vinnik, D Fraemke, A Okbay, D Richter, G G Wagner, R Hertwig, P Koellinger, E M Tucker-Drob, K P Harden, Laurel Raffington

Clinical epigenetics 2024 Feb 08

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Self-control is a personality dimension that is associated with better physical health and a longer lifespan. Here, we examined (1) whether self-control is associated with buccal and saliva DNA-methylation (DNAm) measures of biological aging quantified in children, adolescents, and adults, and (2) whether biological aging measured in buccal DNAm is associated with self-reported health. Following preregistered analyses, we computed two DNAm measures of advanced biological age (principal-component PhenoAge and GrimAge Acceleration) and a DNAm measure of pace of aging (DunedinPACE) in buccal samples from the German Socioeconomic Panel Study (SOEP-G[ene], n = 1058, age range 0-72, Mage = 42.65) and saliva samples from the Texas Twin Project (TTP, n = 1327, age range 8-20, Mage = 13.50). We found that lower self-control was associated with advanced biological age in older adults (PhenoAge Acceleration β = - .34, [- .51, - .17], p < .001; GrimAge Acceleration β = - .34, [- .49, - .19], p < .001), but not young adults, adolescents or children. These associations remained statistically robust even after correcting for possible confounders such as socioeconomic contexts, BMI, or genetic correlates of low self-control. Moreover, a faster pace of aging and advanced biological age measured in buccal DNAm were associated with self-reported disease (PhenoAge Acceleration: β = .13 [.06, .19], p < .001; GrimAge Acceleration: β = .19 [.12, .26], p < .001; DunedinPACE: β = .09 [.02, .17], p = .01). However, effect sizes were weaker than observations in blood, suggesting that customization of DNAm aging measures to buccal and saliva tissues may be necessary. Our findings are consistent with the hypothesis that self-control is associated with health via pathways that accelerate biological aging in older adults. © 2024. The Author(s).

Citation

Y E Willems, A deSteiguer, P T Tanksley, L Vinnik, D Fraemke, A Okbay, D Richter, G G Wagner, R Hertwig, P Koellinger, E M Tucker-Drob, K P Harden, Laurel Raffington. Self-control is associated with health-relevant disparities in buccal DNA-methylation measures of biological aging in older adults. Clinical epigenetics. 2024 Feb 08;16(1):22