Progress in the Correlation Between Inflammasome NLRP3 and Liver Fibrosis.

Liver fibrosis is a reversible condition that occurs in the early stages of chronic liver disease. To develop effective treatments for liver fibrosis, understanding the underlying mechanism is crucial. The NOD-like receptor protein 3 (NLRP3) inflammasome, which is a part of the innate immune system, plays a crucial role in the progression of various inflammatory diseases. NLRP3 activation is also important in the development of various liver diseases, including viral hepatitis, alcoholic or nonalcoholic liver disease, and autoimmune liver disease. This review discusses the role of NLRP3 and its associated molecules in the development of liver fibrosis. It also highlights the signal pathways involved in NLRP3 activation, their downstream effects on liver disease progression, and potential therapeutic targets in liver fibrosis. Further research is encouraged to develop effective treatments for liver fibrosis. © 2024 Authors.

Citation

Meihua Sun, Yanqing Zhang, Anbing Guo, Zongting Xia, Lijun Peng. Progress in the Correlation Between Inflammasome NLRP3 and Liver Fibrosis. Journal of clinical and translational hepatology. 2024 Feb 28;12(2):191-200

PMID: 38343611

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