Ti(III)-Catalyzed Anti-Markovnikov Reduction of Epoxides with Borohydride.

Guangchen Li, Jack R Norton

Organic letters 2024 Feb 23

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We have developed a Ti catalyst that carries out the anti-Markovnikov reduction of a wide range of epoxides; [BH4]- is used as both the electron and the hydrogen atom source. It requires only mild conditions and accommodates a broad range of epoxide substrates. The Ti catalyst is readily available and is environmentally friendly.

Citation

Guangchen Li, Jack R Norton. Ti(III)-Catalyzed Anti-Markovnikov Reduction of Epoxides with Borohydride. Organic letters. 2024 Feb 23;26(7):1382-1386

PMID: 38350153

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