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The inflow channel of the glymphatic pathway is the basilar membrane formed by the pia matter and glial border membrane in the outermost layer of the artery. Cerebrospinal fluid from the subarachnoid space enters the brain parenchyma through this pathway, and its water component is pumped into the brain parenchyma through aquaporin 4. One of the driving forces is vascular pulsation, and if this pathway becomes inoperative, cerebrospinal fluid loses its normal dynamics and contributes to idiopathic normal pressure hydrocephalus. Future research is needed to determine the extent of this contribution to the development of idiopathic normal pressure hydrocephalus.

Citation

Masafumi Ihara. Glymphatic System and Idiopathic Normal Pressure Hydrocephalus]. Brain and nerve = Shinkei kenkyu no shinpo. 2024 Feb;76(2):117-122

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PMID: 38351557

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