Neutrophils are heterogeneous, but the mechanisms underlying their ability to polarize remain unclear. In this issue of Immunity, Gour et al. demonstrate that the GPCR Mrgpra1 and the neuropeptide NPFF, molecules involved in pain and itch, direct neutrophil polarization that impacts host defense and pneumonia susceptibility. Copyright © 2024 Elsevier Inc. All rights reserved.
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Carlos H Hiroki, Bryan G Yipp. Neutrophils are itching to specialize. Immunity. 2024 Feb 13;57(2):198-200
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PMID: 38354698
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