Sesquiterpenoids and Cytochalasins with Immunosuppressive Activity from Sonchus wightianus.

Zhi-Xiang Xie, Yong-Sheng Cui, Xi-Hong Liu, Jia-Ying Yao, Shi-Jun He, Bin Zhou, Jian-Min Yue

Chemistry & biodiversity 2024 Apr

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The plant species, Sonchus wightianus DC., was historically used in China for both medicinal and dietary uses. In present study, seven new guaiane sesquiterpenoids (1-7) and one cytochalasin (8), along with five known guaianes (9-13) and two known cytochalasins (14 and 15), were isolated from the whole plants of S. wightianus. These guaianes showed structural variations in the substituents at C-8 and/or C-15, and compounds 6 and 7 are two sesquiterpenoid glycoside derivatives. Their structures were determined by extensive analysis of spectroscopic, electronic circular dichroism, and X-ray diffraction data, and chemical method. Biological tests revealed that compounds 5 and 8 are potent and selective immunosuppressive reagents. © 2024 Wiley‐VHCA AG, Zurich, Switzerland.

Citation

Zhi-Xiang Xie, Yong-Sheng Cui, Xi-Hong Liu, Jia-Ying Yao, Shi-Jun He, Bin Zhou, Jian-Min Yue. Sesquiterpenoids and Cytochalasins with Immunosuppressive Activity from Sonchus wightianus. Chemistry & biodiversity. 2024 Apr;21(4):e202400256