Functional metal-phenolic cortical cytoskeleton for artificial cells.

Cortex-like cytoskeleton, a thin layer of cross-linked cytoplasmic proteins underlying the cell membrane, plays an essential role in modulating membrane behavior and cell surface properties. However, bottom-up construction of functional cortex-like cytoskeleton in artificial cells remains a challenge. Here, we present metal-phenolic networks as artificial cortical cytoskeletons in liposome-based artificial cells. The metal-phenolic cytoskeleton-reinforced artificial cells exhibit long-term stability, enhanced resistance to a variety of harsh environments, tunable permeability, and well-controlled morphologies. We anticipate that our stable artificial cell models will stride forward to practical applications of liposome-based microsystem.

Citation

Zhen-Hong Luo, Chen Chen, Qi-Hong Zhao, Nan-Nan Deng. Functional metal-phenolic cortical cytoskeleton for artificial cells. Science advances. 2024 Feb 16;10(7):eadj4047

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PMID: 38363847

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