Abietane diterpenoids with anti-neuroinflammation activity from Rosmarinus officinalis.

Tang Zhou, Ji Wang, Zhiqi Lin, Hongbo Zhu, Weiyan Hu, Rongping Zhang, Xinglong Chen

Fitoterapia 2024 Apr

filter terms:

A total of 12 abietane diterpenoids were isolated and identified from Rosmarinus officinalis in which 6 ones were undescribed compounds. Their structures were illuminated by the HRESIMS, NMR, and ECD methods and named as rosmarinusin Q-V (1-6). It worthy mentioned that rosmarinusin Q was a novel abietane diterpenoid with 6/6/5 skeleton whose C ring was an α,β-unsaturated five-element ketone. All the compounds and four compounds (13-16) reported in our previous paper were evaluated their anti-neuroinflammatory activities on the LPS-induced BV2 cells. Compounds 5, 8, 9, 11, and 15 displayed significant anti-neuroinflammatory activity at the concentration of 10, 20, and 40 μM respectively. These results confirmed that R. officinalis contained abundant abietane diterpenoids and these compounds showed potential values of anti-neuroinflammation which could be developed as neuroprotective agents for the treatment of nerve damage caused by inflammation. Copyright © 2024 Elsevier B.V. All rights reserved.

Citation

Tang Zhou, Ji Wang, Zhiqi Lin, Hongbo Zhu, Weiyan Hu, Rongping Zhang, Xinglong Chen. Abietane diterpenoids with anti-neuroinflammation activity from Rosmarinus officinalis. Fitoterapia. 2024 Apr;174:105866