Possible case of bortezomib-induced ileus paralytic.

Nikhil Aravind, Niveditha Krishnappa, Nusrat Shafiq, Pankaj Malhotra

BMJ case reports 2024 Feb 21

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This report describes a case of a patient with active multiple myeloma who was started on bortezomib, cyclophosphamide and dexamethasone and subsequently presented to the emergency department with acute intestinal obstruction one week later. The patient underwent exploratory laparotomy, but no mechanical cause of the obstruction was found. The patient later developed sepsis and eventually died. The possible cause of the intestinal obstruction was attributed to bortezomib, and the paper discusses the potential mechanism of this side effect and its management based on available literature. © BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.

Citation

Nikhil Aravind, Niveditha Krishnappa, Nusrat Shafiq, Pankaj Malhotra. Possible case of bortezomib-induced ileus paralytic. BMJ case reports. 2024 Feb 21;17(2)