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The population < 60 years of age is also affected by a significant disease burden from seasonal influenza. It carries a high economic burden, mainly driven by influenza-associated productivity losses in the working population. Conventional egg-based influenza vaccines may experience reduced effectiveness due to antigen adaptation in eggs. In contrast, cell-based influenza vaccines are less likely to be affected by antigenic adaptations to the host system and showed better effectiveness in individuals 4-64 years old over several seasons compared to conventional egg-based influenza vaccines under real-world conditions. Preferential use of cell-based influenza vaccines, as opposed to conventional egg-based vaccines, could reduce the burden of influenza-related symptoms on individuals and alleviate the economic impact on the German population < 60 years of age. © 2024. The Author(s).


Barbara C Gärtner, Dietmar Beier, Gunther Gosch, Klaus Wahle, Luise Wendt, Laura-Christin Förster, Kim J Schmidt, Tino F Schwarz. Cell-based influenza vaccines: an effective vaccine option for under 60-year-olds]. Wiener klinische Wochenschrift. 2024 Feb;136(Suppl 2):35-42

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PMID: 38393348

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