HIV-1 envelope diversity and sensitivity to broadly neutralizing antibodies across stages of acute HIV-1 infection.

AIDS (London, England) 2024 Mar 15

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We studied the relationship between viral diversity and susceptibility to broadly neutralizing antibodies (bNAbs) in longitudinal plasma and peripheral blood mononuclear cells from 89 people with HIV who initiated antiretroviral therapy (ART) during acute and early HIV-1 infection (AEHI). HIV-1 diversity and predicted bNAb susceptibility were comparable across AEHI. Diversity evolution was not observed during ART, suggesting (pro)viruses at initiation or during treatment may identify individuals with susceptible virus for bNAb interventional trials. Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.

Citation

Laurie A VanderVeen, Lisa Selzer, Brian Moldt, Aiyappa Parvangada, Jiani Li, Jintanat Ananworanich, Trevor A Crowell, Joseph J Eron, Eric S Daar, Richard Haubrich, Romas Geleziunas, Joshua Cyktor, John W Mellors, Christian Callebaut. HIV-1 envelope diversity and sensitivity to broadly neutralizing antibodies across stages of acute HIV-1 infection. AIDS (London, England). 2024 Mar 15;38(4):607-610