Correlation Engine 2.0
Clear Search sequence regions


  • alveolar bone loss (1)
  • Cd301b (12)
  • chronic disease (1)
  • help (1)
  • macrophage (14)
  • mice (2)
  • mitogen (2)
  • p38 (2)
  • p38 MAPK (2)
  • phagocytosis (1)
  • protein kinases (2)
  • rna (2)
  • TIM 4 (1)
  • Tim4 (8)
  • Timd4 (2)
  • tooth loss (1)
  • Sizes of these terms reflect their relevance to your search.

    Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately result in tooth loss. With the progression of periodontitis, the osteoimmunology microenvironment in periodontitis is damaged and leads to the formation of pathological alveolar bone resorption. CD301b+ macrophages are specific to the osteoimmunology microenvironment, and are emerging as vital booster for conducting bone regeneration. However, the key upstream targets of CD301b+ macrophages and their potential mechanism in periodontitis remain elusive. In this study, we concentrated on the role of Tim4, a latent upstream regulator of CD301b+ macrophages. We first demonstrated that the transcription level of Timd4 (gene name of Tim4) in CD301b+ macrophages was significantly upregulated compared to CD301b- macrophages via high-throughput RNA sequencing. Moreover, several Tim4-related functions such as apoptotic cell clearance, phagocytosis and engulfment were positively regulated by CD301b+ macrophages. The single-cell RNA sequencing analysis subsequently discovered that Cd301b and Timd4 were specifically co-expressed in macrophages. The following flow cytometric analysis indicated that Tim4 positive expression rates in total macrophages shared highly synchronized dynamic changes with the proportions of CD301b+ macrophages as periodontitis progressed. Furthermore, the deficiency of Tim4 in mice decreased CD301b+ macrophages and eventually magnified alveolar bone resorption in periodontitis. Additionally, Tim4 controlled the p38 MAPK signaling pathway to ultimately mediate CD301b+ macrophages phenotype. In a word, Tim4 might regulate CD301b+ macrophages through p38 MAPK signaling pathway in periodontitis, which provided new insights into periodontitis immunoregulation as well as help to develop innovative therapeutic targets and treatment strategies for periodontitis. © 2024. The Author(s).

    Citation

    Ziming Wang, Hao Zeng, Can Wang, Jiaolong Wang, Jing Zhang, Shuyuan Qu, Yue Han, Liu Yang, Yueqi Ni, Wenan Peng, Huan Liu, Hua Tang, Qin Zhao, Yufeng Zhang. Tim4 deficiency reduces CD301b+ macrophage and aggravates periodontitis bone loss. International journal of oral science. 2024 Feb 28;16(1):20

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 38418808

    View Full Text