Mass spectrometric analysis strategies for pyrrolizidine alkaloids.

Yilin Chen, Linnan Li, Jie Xu, Yamin Liu, Yanqiao Xie, Aizhen Xiong, Zhengtao Wang, Li Yang

Food chemistry 2024 Jul 01

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Pyrrolizidine alkaloids (PAs) in food and natural preparations have received widespread attention due to their hepatotoxicity, genotoxicity, and embryotoxicity. Mass spectrometry (MS), as a high resolution, high sensitive, and high throughput detection tool, has been the most commonly used technique for the determination of PAs. The continuous advancement of new technologies, methods, and strategies in the field of MS has contributed to the improvement of the analytical efficiency and methodological enhancement of PAs. This paper provides an overview of the structure, toxicity properties and commonly employed analytical methods, focusing on the concepts, advances, and novel techniques and applications of MS-based methods for the analysis of PAs. Additionally, the remaining challenges, future perspectives, and trends for PA detection are discussed. This review provides a reference for toxicological studies of PAs, content monitoring, and the establishment of quality control and safety standards for herbal and food products. Copyright © 2024 Elsevier Ltd. All rights reserved.

Citation

Yilin Chen, Linnan Li, Jie Xu, Yamin Liu, Yanqiao Xie, Aizhen Xiong, Zhengtao Wang, Li Yang. Mass spectrometric analysis strategies for pyrrolizidine alkaloids. Food chemistry. 2024 Jul 01;445:138748