Expression and function of VISTA on myeloid cells.

Siyu Li, Geng Wang, Yan Ren, Xinyue Liu, Yixuan Wang, Jianing Li, Hua Liu, Jiaqiang Yang, Jingjun Xing, Yanru Zhang, Canxia He, Suling Xu, Xin Hou, Na Li

Biochemical pharmacology 2024 Apr

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V-domain containing Ig Suppressor of T cell Activation (VISTA) is predominantly expressed on myeloid cells and functions as a ligand/receptor/soluble molecule. In inflammatory responses and immune responses, VISTA regulates multiple functions of myeloid cells, such as chemotaxis, phagocytosis, T cell activation. Since inflammation and immune responses are critical in many diseases, VISTA is a promising therapeutic target. In this review, we will describe the expression and function of VISTA on different myeloid cells, including neutrophils, monocytes, macrophages, dendritic cells (DCs), myeloid-derived suppressor cells (MDSCs). In addition, we will discuss whether the functions of VISTA on these cells impact the disease processing. Copyright © 2024 Elsevier Inc. All rights reserved.

Citation

Siyu Li, Geng Wang, Yan Ren, Xinyue Liu, Yixuan Wang, Jianing Li, Hua Liu, Jiaqiang Yang, Jingjun Xing, Yanru Zhang, Canxia He, Suling Xu, Xin Hou, Na Li. Expression and function of VISTA on myeloid cells. Biochemical pharmacology. 2024 Apr;222:116100