Beyond cyclopamine: Targeting Hedgehog signaling for cancer intervention.

Beena Thazhackavayal Baby, Aniruddha Murahar Kulkarni, Prasanna Kumar Reddy Gayam, Kuzhuvelil B Harikumar, Jesil Mathew Aranjani

Archives of biochemistry and biophysics 2024 Apr

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Hedgehog (Hh) signaling plays a significant role in embryogenesis and several physiological processes, such as wound healing and organ homeostasis. In a pathological setting, it is associated with oncogenesis and is responsible for disease progression and poor clinical outcomes. Hedgehog signaling mediates downstream actions via Glioma Associated Oncogene Homolog (GLI) transcription factors. Inhibiting Hh signaling is an important oncological strategy in which inhibitors of the ligands SMO or GLI have been looked at. This review briefly narrates the Hh ligands, signal transduction, the target genes involved and comprehensively describes the numerous inhibitors that have been evaluated for use in various neoplastic settings. Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

Beena Thazhackavayal Baby, Aniruddha Murahar Kulkarni, Prasanna Kumar Reddy Gayam, Kuzhuvelil B Harikumar, Jesil Mathew Aranjani. Beyond cyclopamine: Targeting Hedgehog signaling for cancer intervention. Archives of biochemistry and biophysics. 2024 Apr;754:109952