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Pinoresinol diglucoside mitigates dexamethasone-induced osteoporosis and chondrodysplasia in zebrafish.

Yuhua Zuo, Chao Chen, Fasheng Liu, Hongmei Hu, Si Dong, Qinyuan Shen, Junquan Zeng, Ling Huang, Xinjun Liao, Zigang Cao, Zilin Zhong, Huiqiang Lu, Jianjun Chen

Toxicology and applied pharmacology 2024 Mar


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    The global increase in the aging population has led to a higher incidence of osteoporosis among the elderly. This study aimed to evaluate the protective properties of pinoresinol diglucoside (PDG), an active constituent of Eucommia ulmoides, against dexamethasone-induced osteoporosis and chondrodysplasia. A zebrafish model of osteoporosis was established by exposing larval zebrafish to dexamethasone. The impact of PDG on bone mineralization was assessed through alizarin red and calcein staining. Alkaline phosphatase activity was quantified to evaluate osteoblast function. The influence of PDG on chondrogenesis was estimated using alcian blue staining. Fluorescence imaging and motor behavior analysis were employed to assess the protective effect of PDG on the structure and function of dexamethasone-induced skeletal teratogenesis. qPCR determined the expression of osteogenesis and Wnt signaling-related genes. Molecular docking was used to assess the potential interactions between PDG and Wnt receptors. PDG significantly increased bone mineralization and corrected spinal curvature and cartilage malformations in the zebrafish model. Furthermore, PDG enhanced swimming abilities compared to the model group. PDG mitigated dexamethasone-induced skeletal abnormalities in zebrafish by upregulating Wnt signaling, showing potential interaction with Wnt receptors FZD2 and FZD5. PDG mitigates dexamethasone-induced osteoporosis and chondrodysplasia by promoting bone formation and activating Wnt signaling. Copyright © 2024 Elsevier Inc. All rights reserved.

    Citation

    Yuhua Zuo, Chao Chen, Fasheng Liu, Hongmei Hu, Si Dong, Qinyuan Shen, Junquan Zeng, Ling Huang, Xinjun Liao, Zigang Cao, Zilin Zhong, Huiqiang Lu, Jianjun Chen. Pinoresinol diglucoside mitigates dexamethasone-induced osteoporosis and chondrodysplasia in zebrafish. Toxicology and applied pharmacology. 2024 Mar;484:116884

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    PMID: 38442791

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