SIRT1: An Intermediator of Key Pathways Regulating Pulmonary Diseases.

Silent information regulator type-1 (SIRT1), a nicotinamide adenine dinucleotide+-dependent deacetylase, is a member of the sirtuins family and has unique protein deacetylase activity. SIRT1 participates in physiological as well as pathophysiological processes by targeting a wide range of protein substrates and signalings. In this review, we described the latest progress of SIRT1 in pulmonary diseases. We have introduced the basic information and summarized the prominent role of SIRT1 in several lung diseases, such as acute lung injury, acute respiratory distress syndrome, chronic obstructive pulmonary disease, lung cancer, and aging-related diseases. Copyright © 2024 United States & Canadian Academy of Pathology. Published by Elsevier Inc. All rights reserved.

Citation

Yi-Zhu Jiang, Xin-Ran Huang, Jing Chang, Yong Zhou, Xiao-Ting Huang. SIRT1: An Intermediator of Key Pathways Regulating Pulmonary Diseases. Laboratory investigation; a journal of technical methods and pathology. 2024 May;104(5):102044

Mesh Tags

Substances

PMID: 38452903

search → result