The Hippo signaling pathway in development and regeneration.

Zhenxing Zhong, Zhihan Jiao, Fa-Xing Yu

Cell reports 2024 Mar 26

filter terms:

The Hippo signaling pathway is a central growth control mechanism in multicellular organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo pathway orchestrates proliferation, survival, differentiation, and mechanics of cells, which in turn regulate organ development, homeostasis, and regeneration. A deep understanding of the regulation and function of the Hippo pathway therefore holds great promise for developing novel therapeutics in regenerative medicine. Here, we provide updates on the molecular organization of the mammalian Hippo signaling network, review the regulatory signals and functional outputs of the pathway, and discuss the roles of Hippo signaling in development and regeneration. Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.