Application of Aleppo pine extract for skin burn treatment.

Journal of applied biomaterials & functional materials 2024 Jan-Dec

filter terms:

To investigate the Pinus halepensis extracts and determine its healing and antibacterial effects, and to evaluate the treatment of skin burns. Aqueous and ethanolic extracts and topical based on Aleppo pine plant extracts were prepared. Thirty male and female Wistar rats were used to study the cutaneous toxicity of extracts from the bark of P. halepensis. The extracts' healing potential for burn wounds were also assessed by evaluating the clinical and macroscopic aspects of the wounds. The antibacterial activity of crude extracts of P. halepensis as well as its wound healing abilities was verified in this investigation. In animals with acute dermal toxicity, there were no signs of treatment-related toxicity or death. The extracts of these plants could be transformed into phytomedicines for the treatment of infected wounds. The results demonstrated that formulated ointments are successful in treating second-degree burns in rats and may be suitable for the short-term therapeutic treatment of second-degree burns. This study successfully answered our problem, regarding the efficacy of our extract for treating second-degree burns in rats. Further studies are needed to confirm these results by identifying the molecules responsible for these activities and examining their mechanism of action.

Citation

Najoua Salhi, Otman El Guourrami, Abdelaali Balahbib, Lamiae Rouas, Siham Moussaid, Amina Moutawalli, Fatima Zahra Benkhouili, Mouna Ameggouz, Riaz Ullah, Amal Alotaibi, Abdelhakim Bouyahya, Ching Siang Tan, Long Chiau Ming, My El Abbes Faouzi, Yahya Cherrah. Application of Aleppo pine extract for skin burn treatment. Journal of applied biomaterials & functional materials. 2024 Jan-Dec;22:22808000241236020