Synthesis of Unnatural Amino Acids via Ni/Ag Electrocatalytic Cross-Coupling.

A simple protocol is outlined herein for rapid access to enantiopure unnatural amino acids (UAAs) from trivial glutamate and aspartate precursors. The method relies on Ag/Ni-electrocatalytic decarboxylative coupling and can be rapidly conducted in parallel (24 reactions at a time) to ascertain coupling viability followed by scale-up for the generation of useful quantities of UAAs for exploratory studies.

Citation

Gabriele Laudadio, Philipp Neigenfind, Rajesh Chebolu, Vanna D Blasczak, Shambabu Joseph Maddirala, Maximilian D Palkowitz, Philippe N Bolduc, Michael C Nicastri, Ravi Kumar Puthukanoori, Bheema Rao Paraselli, Phil S Baran. Synthesis of Unnatural Amino Acids via Ni/Ag Electrocatalytic Cross-Coupling. Organic letters. 2024 Mar 22;26(11):2276-2281

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PMID: 38467055

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