Cross-linked Triblock Peptide Capsules as Potential Oxygen Carriers.

ChemistryOpen 2024 Apr

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Perfluorodecalin (PFD)-filled capsules have been studied for over 15 years as artificial oxygen carriers. However, none of these capsules combines good biocompatibility, good mechanical stability and dispersion stability. Here we propose to use synthetic triblock peptides containing a central block of cysteine units as a cross-linking shell material for capsules with both good biocompatibility and stability. Together with outer aspartate units and inner phenylalanine units, the resulting amphiphilic triblock peptides can encapsulate PFD efficiently to prepare capsules with a suitable diameter, a certain mechanical strength, a large diffusion constant, fast gas exchange rates, and little cytotoxicity. Given the above advantages, these PFD-filled peptide capsules are very promising as potential artificial oxygen carriers. © 2024 The Authors. ChemistryOpen published by Wiley-VCH GmbH.

Citation

Huayang Feng, Jürgen Linders, Miriam Cantore, Jonas Fabrizi, Annika Kirsten, Sascha Myszkowska, Eva Hillen, Florian Uteschil, Sebastian Buchholz, Andrea Hermsen, Maria Davila Garvin, Katja Bettina Ferenz, Christian Mayer. Cross-linked Triblock Peptide Capsules as Potential Oxygen Carriers. ChemistryOpen. 2024 Apr;13(4):e202300282