Semaphorins and the bone marrow microenvironment: New candidates that influence the hematopoietic system.

Carlos E da Silva Gonçalves, Ricardo A Fock

Cytokine & growth factor reviews 2024 Apr

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The bone marrow is a haven for hematopoietic and non-hematopoietic cells, creating complex micro-anatomical regions called niches. These distinct niches all participate in an intricate orchestra of cellular interactions that regulates the hematopoietic stem cell and its progenies. In this review, we provide a detailed description of the three most well-known bone marrow niches and their participation in hematopoiesis. We use pre-clinical data, including different in vitro and in vivo studies to discuss how a group of proteins called Semaphorins could potentially modulate both hematopoietic and non-hematopoietic cells, establishing links between the niches, semaphorins, and hematopoietic regulation. Thus, here we provide a deep dive into the inner functioning of the bone marrow and discuss the overarching implications that semaphorins might have on blood formation. Copyright © 2024 Elsevier Ltd. All rights reserved.

Citation

Carlos E da Silva Gonçalves, Ricardo A Fock. Semaphorins and the bone marrow microenvironment: New candidates that influence the hematopoietic system. Cytokine & growth factor reviews. 2024 Apr;76:22-29