A DNA tetrahedron dimer for dual membrane protein logic recognition and interaction inhibition.

Yuanmeng Zhang, Muyang Lin, Jingkang Yao, Xiaowen Xu

Chemical communications (Cambridge, England) 2024 Mar 28

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Here, we report a DNA tetrahedron dimer for dual membrane protein logic recognition and interaction inhibition. The DNA tetrahedron dimer not only detects dual proteins that are both overexpressed on target cells in "AND" logic, but also inhibits protein interaction by steric hindrance to suppress cell proliferation, offering new insights for cancer cell diagnosis and treatment.

Citation

Yuanmeng Zhang, Muyang Lin, Jingkang Yao, Xiaowen Xu. A DNA tetrahedron dimer for dual membrane protein logic recognition and interaction inhibition. Chemical communications (Cambridge, England). 2024 Mar 28;60(27):3721-3724