A comprehensive review of lncRNA CRNDE in cancer progression and pathology, with a specific glance at the epithelial-mesenchymal transition (EMT) process.

It has been suggested that the long non-coding RNAs (lncRNAs), such as colorectal neoplasia differentially expressed (CRNDE), may contribute to the formation of human cancer. It is yet unknown, though, what therapeutic significance CRNDE expression has for different forms of cancer. CRNDE has recently been proposed as a possible diagnostic biomarker and prognostic pred for excellent specificity and sensitivity in cancer tissues and plasma. To provide the groundwork for potential future therapeutic uses of CRNDE, we briefly overview its biological action and related cancer-related pathways. Next, we mainly address the impact of CRNDE on the epithelial-mesenchymal transition (EMT). The epithelial-mesenchymal transition, or EMT, is an essential biological mechanism involved in the spread of cancer. Copyright © 2024 Elsevier GmbH. All rights reserved.

Citation

Saade Abdalkareem Jasim, Sulieman Ibraheem Shelash Al-Hawary, Ahmed Hjazi, Irfan Ahmad, Irwanjot Kaur, Wesam R Kadhum, Adnan Taan Alkhafaji, Pallavi Ghildiyal, Mohammed Abed Jawad, Salim B Alsaadi. A comprehensive review of lncRNA CRNDE in cancer progression and pathology, with a specific glance at the epithelial-mesenchymal transition (EMT) process. Pathology, research and practice. 2024 Apr;256:155229

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PMID: 38484655

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