Case Study: Rosai-Dorfman Disease and Its Multifaceted Aspects.

Rosai-Dorfman Disease (RDD) is a rare non-Langerhans histiocytosis, usually self-limited and presenting with massive, painless, bilateral cervical lymphadenopathy, with or without constitutional symptoms. Extranodal disease is frequently present, and may happen in the absence of lymph node involvement, symptomatology and differential diagnosis will depend on the site affected and fatal cases may occur. The authors present two cases of Rosai-Dorfman disease (RDD), diagnosed through immunohistochemistry, with different progressions, one with complete remission and one culminating in death, highlighting the variety of presentations and the diagnostic difficulty. RDD is a rare condition with clinical presentations similar to several diseases, and should be considered in the differential diagnosis of lymphadenopathy with extranodal lesions. © 2024 Werneck Rodrigues et al.

Citation

Daniela Oliveira Werneck Rodrigues, Roberta Wolp Diniz, Leonardo Cunha Dentz, Monica de Albuquerque Costa, Roberto Heleno Lopes, Lucas Fernandes Suassuna, Jane Rocha Duarte Cintra, Christian Domenge. Case Study: Rosai-Dorfman Disease and Its Multifaceted Aspects. Journal of blood medicine. 2024;15:123-128

PMID: 38495774

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