Dual-wield NTPases: A novel protein family mined from AlphaFold DB.

AlphaFold protein structure database (AlphaFold DB) archives a vast number of predicted models. We conducted systematic data mining against AlphaFold DB and discovered an uncharacterized P-loop NTPase family. The structure of the protein family was surprisingly novel, showing an atypical topology for P-loop NTPases, noticeable twofold symmetry, and two pairs of independent putative active sites. Our findings show that structural data mining is a powerful approach to identifying undiscovered protein families. © 2024 The Authors. Protein Science published by Wiley Periodicals LLC on behalf of The Protein Society.

Citation

Koya Sakuma, Ryotaro Koike, Motonori Ota. Dual-wield NTPases: A novel protein family mined from AlphaFold DB. Protein science : a publication of the Protein Society. 2024 Apr;33(4):e4934

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PMID: 38501460

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