Research progress on the regulatory mechanism of integrin-mediated mechanical stress in cells involved in bone metabolism.

Mechanical stress is an internal force between various parts of an object that resists external factors and effects that cause an object to deform, and mechanical stress is essential for various tissues that are constantly subjected to mechanical loads to function normally. Integrins are a class of transmembrane heterodimeric glycoprotein receptors that are important target proteins for the action of mechanical stress stimuli on cells and can convert extracellular physical and mechanical signals into intracellular bioelectrical signals, thereby regulating osteogenesis and osteolysis. Integrins play a bidirectional regulatory role in bone metabolism. In this paper, relevant literature published in recent years is reviewed and summarized. The characteristics of integrins and mechanical stress are introduced, as well as the mechanisms underlying responses of integrin to mechanical stress stimulation. The paper focuses on integrin-mediated mechanical stress in different cells involved in bone metabolism and its associated signalling mechanisms. The purpose of this review is to provide a theoretical basis for the application of integrin-mediated mechanical stress to the field of bone tissue repair and regeneration. © 2024 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

Citation

Li Yang, Hong Chen, Chanchan Yang, Zhengqi Hu, Zhiliang Jiang, Shengzi Meng, Rong Liu, Lan Huang, Kun Yang. Research progress on the regulatory mechanism of integrin-mediated mechanical stress in cells involved in bone metabolism. Journal of cellular and molecular medicine. 2024 Apr;28(7):e18183

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PMID: 38506078

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