Alliaxylines A-E: five new mexicanolides from the stem barks of Dysoxylum alliaceum (Blume) Blume ex A.Juss.

A total of five new mexicanolides (1-5), namely alliaxylines A-E, together with two known limonoids 6 and 7, were isolated and identified from Dysoxylum alliaceum (Blume) Blume ex. A.Juss. (Meliaceae). The structures of these compounds were elucidated based on extensive spectroscopic analyses, including HR-ESI-MS, UV, IR, 1D, and 2D NMR, as well as theoretical stimulation of NMR shifts with the DP4 + algorithm. Consequently, this study aimed to examine cytotoxic activities of these compounds against MCF-7 and A549 cell lines. The results implied that compound 2 was the most potent against the two tested cells, with IC50 values of 34.95 ± 0.21 and 44.39 ± 1.03 µM. © 2024. The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy.

Citation

Sandra Amalia Riyadi, Al Arofatus Naini, Tri Mayanti, Ronny Lesmana, Mohamad Nurul Azmi, Sofa Fajriah, Siriporn Jungsuttiwong, Unang Supratman. Alliaxylines A-E: five new mexicanolides from the stem barks of Dysoxylum alliaceum (Blume) Blume ex A.Juss. Journal of natural medicines. 2024 Jun;78(3):558-567

Mesh Tags

Substances

PMID: 38517622

search → result