A rare case of cutaneous granular cell tumor with unusual Melan-A expression in a child.

Nina H Cheng, David Smith, Carla Errickson, Shaymaa Ashi

Journal of cutaneous pathology 2024 Jun

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Granular cell tumors (GCTs) are rare, indolent neoplasms classically characterized by eosinophilic granular cytoplasm, infiltrations of polygonal cells in the collagenous stroma, and pustulo-ovoid bodies of Milian. We describe a case of a 10-year-old female presenting with a GCT of the upper arm, remarkable for positive Melan-A expression without additional melanocytic features. The differentiation between granular cells versus melanocytic neoplasms carries significant implications for clinical management, and such diagnoses should be considered carefully in the setting of unusual immunophenotypes. © 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Citation

Nina H Cheng, David Smith, Carla Errickson, Shaymaa Ashi. A rare case of cutaneous granular cell tumor with unusual Melan-A expression in a child. Journal of cutaneous pathology. 2024 Jun;51(6):434-438