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Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as a promising tool for combating the disease. The study evaluated plasma metabolomic profiles of patients with recurrent and non-recurrent P. vivax malaria in the Brazilian Amazon. Metabolites extracted from the plasma of P. vivax-infected patients were subjected to LC-MS analysis. Untargeted metabolomics was applied to investigate the metabolic profile of the plasma in the two groups. Overall, 51 recurrent and 59 non-recurrent patients were included in the study. Longitudinal metabolomic analysis revealed 52 and 37 significant metabolite features from the recurrent and non-recurrent participants, respectively. Recurrence was associated with disturbances in eicosanoid metabolism. Comparison between groups suggest alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism, 3-oxo-10-octadecatrienoate β-oxidation, and alkaloid biosynthesis II. Integrative network analysis revealed enrichment of other metabolic pathways for the recurrent phenotype, including the butanoate metabolism, aspartate and asparagine metabolism, and N-glycan biosynthesis. The metabolites and metabolic pathways predicted in our study suggest potential biomarkers of recurrence and provide insights into targets for antimalarial development against P. vivax. © 2024. The Author(s).

Citation

Michael N Yakubu, Victor I Mwangi, Rebeca L A Netto, Maria G C Alecrim, Jessica R S Alves, Anne C G Almeida, Gabriel F Santos, Gesiane S Lima, Lucas S Machado, Hector H F Koolen, Tiago P Guimarães, Andrea R Chaves, Boniek G Vaz, Wuelton M Monteiro, Fabio T M Costa, Marcus V G Lacerda, Luiz G Gardinassi, Gisely C de Melo. Host metabolomic responses in recurrent P. vivax malaria. Scientific reports. 2024 Mar 27;14(1):7249

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PMID: 38538661

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