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The story of p53 is illuminating. Despite widespread attention, the tumor-suppressive functions of wild-type p53 or the oncogenic activities of its cancer-associated mutants are still not fully understood, and our discoveries have not yet led to major therapeutic breakthroughs. There is still much to learn about this fascinating protein. Copyright © 2024 Elsevier Inc. All rights reserved.

Citation

Moshe Oren, Carol Prives. p53: A tale of complexity and context. Cell. 2024 Mar 28;187(7):1569-1573

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PMID: 38552605

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