A case of secondary pseudohypoaldosteronism that presented as poor weight gain.

Pseudohypoaldosteronism (PHA) carries a good prognosis if treated early and appropriately, but some cases can have life-threatening events. We underscored the need to consider secondary PHA as one of the differential diagnoses of hyponatremia and hyperkalemia in infancy. Pseudohypoaldosteronism (PHA) type 1 has two classifications; the primary type, caused by genetic abnormalities that develop during neonatal and infancy periods, and the secondary type, caused by urinary tract malformation and urinary tract infection. Secondary PHA, if treated early and appropriately, has a good prognosis; however, some cases can present life-threatening events. Therefore, early diagnosis is crucial. We present a case of early infancy secondary PHA presented with marked hyponatremia and poor weight gain. The patient's growth and development improved with secondary PHA treatment. Here, were demonstrated the value of prompt action against infection and electrolyte imbalance and the importance of imaging for diagnosis, and underscore the need to consider secondary PHA as a differential diagnoses of hyponatremia and hyperkalemia in infancy. However further studies, including basic research, to elucidate the diseases pathology is warranted. © 2024 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

Citation

Keisuke Goshima, Hiroshi Tamura, Yuko Hidaka, Keishiro Furuie, Shohei Kuraoka. A case of secondary pseudohypoaldosteronism that presented as poor weight gain. Clinical case reports. 2024 Apr;12(4):e8722

PMID: 38562574

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