Stressing the Role of CCL3 in Reversing the Immunosuppressive Microenvironment in Gliomas.

Patients with gliomas often experience mental health problems, such as depression and anxiety, that lead to worsening tumor progression and shortened survival. In this issue, Wang and colleagues report a novel mechanism underlying this, finding that chronic stress reduces secretion of the chemokine CCL3, which leads to an immunosuppressive glioma microenvironment. CCL3 administration enhances the infiltration of antitumor immune cells, providing rationale for a potential new therapeutic approach. See related article by Wang et al., p. 516 (4). ©2024 American Association for Cancer Research.

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Xiaoteng Cui, Chunsheng Kang. Stressing the Role of CCL3 in Reversing the Immunosuppressive Microenvironment in Gliomas. Cancer immunology research. 2024 May 02;12(5):514

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PMID: 38568780

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