Insecticidal bisindole alkaloids from leaves of Tabernaemontana divaricata 'Dwaft'.

Six undescribed bisindole alkaloids, namely taberdisines A-F (1-6), were isolated from the leaves of Tabernaemontana divaricata 'Dwaft'. Among them, alkaloids 1 and 2 were the first examples of strychnos-iboga type alkaloid with both C-C linkage patterns. Alkaloid 3, a new type of aspidosperma-iboga with a furan-ring, as well as other three undescribed ones was disclosed. Their structures were elucidated by comprehensive spectroscopic analyses. Alkaloids 1 and 5 showed insecticide activity on Sf9 cell and eggs of Spodoptera frugiperda in vivo, which might explain the potential of the plants for insect resistance. Copyright © 2024 Elsevier Ltd. All rights reserved.

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Jing Chen, Sumet Kongkiatpaiboon, Xiang-Hai Cai. Insecticidal bisindole alkaloids from leaves of Tabernaemontana divaricata 'Dwaft'. Phytochemistry. 2024 Jun;222:114075

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PMID: 38570006

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