Intertwined relationship of dynamin-related protein 1, mitochondrial metabolism and circadian rhythm.

Indrani Paramasivan Latha Laxmi, Anica Tholath Job, Venkatraman Manickam, Ramasamy Tamizhselvi

Molecular biology reports 2024 Apr 05

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In recent years, mitochondria have gained significant interest in the field of biomedical research due to their impact on human health and ageing. As mitochondrial dynamics are strongly controlled by clock genes, misalignment of the circadian rhythm leads to adverse metabolic health effects. In this review, by exploring various aspects of research and potential links, we hope to update the current understanding of the intricate relationship between DRP1-mediated mitochondrial dynamics and changes in circadian rhythmicity leading to health issues. Thus, this review addresses the potential bidirectional relationships between DRP1-linked mitochondrial function and circadian rhythm misalignment, their impact on different metabolic pathways, and the potential therapeutics for metabolic and systemic disorders. © 2024. The Author(s), under exclusive licence to Springer Nature B.V.

Citation

Indrani Paramasivan Latha Laxmi, Anica Tholath Job, Venkatraman Manickam, Ramasamy Tamizhselvi. Intertwined relationship of dynamin-related protein 1, mitochondrial metabolism and circadian rhythm. Molecular biology reports. 2024 Apr 05;51(1):488