Tenascin-C targeting strategies in cancer.

Tenascin-C (TNC) is a matricellular and multimodular glycoprotein highly expressed under pathological conditions, especially in cancer and chronic inflammatory diseases. Since a long time TNC is considered as a promising target for diagnostic and therapeutic approaches in anti-cancer treatments and was already extensively targeted in clinical trials on cancer patients. This review provides an overview of the current most advanced strategies used for TNC detection and anti-TNC theranostic approaches including some advanced clinical strategies. We also discuss novel treatment protocols, where targeting immune modulating functions of TNC could be center stage. Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.

Citation

Sayda Dhaouadi, Balkiss Bouhaouala-Zahar, Gertraud Orend. Tenascin-C targeting strategies in cancer. Matrix biology : journal of the International Society for Matrix Biology. 2024 Jun;130:1-19

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PMID: 38642843

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