Self-assembled tetrazine cryptophane for ion pair recognition and guest release by cage disassembly.

Hereby, we describe the synthesis of a self-assembled syn-cryptophane using dynamic nucleophilic aromatic substitution of tetrazines. 1H NMR cage titrations reveal that the tetramethylammonium cation binds under slow exchange conditions while counter-anions show a fast exchange regime. Finally, the cryptophane can be disassembled by the addition of thiols allowing guest release.

Citation

Louise Miton, Elise Antonetti, Marie Poujade, Jean-Pierre Dutasta, Paola Nava, Alexandre Martinez, Yoann Cotelle. Self-assembled tetrazine cryptophane for ion pair recognition and guest release by cage disassembly. Chemical communications (Cambridge, England). 2024 May 09;60(39):5217-5220

PMID: 38656223

search → result