A morphological mimic: An NTRK3-rearranged spindle cell neoplasm presenting as a groin mass.

Neurotrophic receptor tyrosine kinase (NTRK)-rearranged spindle cell neoplasms are a recently described group of soft tissue tumors. They commonly present as a painless mass on the extremities of children and young adults. They are characterized microscopically by a heterogeneous spectrum of infiltrative spindle cell proliferations, which can morphologically mimic several other spindle cell neoplasms. Their identification is vital, as they may be amenable to treatment with tyrosine kinase-targeted therapy. This case report describes a rare NTRK3-rearranged spindle cell neoplasm in the groin of a 29-year-old female and provides further clinical and morphological features of this entity. © 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Citation

Bethany Shelvey, Stefan Dojcinov, Manuela Roman, Iain S Whitaker, Emma Short. A morphological mimic: An NTRK3-rearranged spindle cell neoplasm presenting as a groin mass. Journal of cutaneous pathology. 2024 Aug;51(8):572-575

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PMID: 38661100

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